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Novel ligands designed to activate mu opioid receptors and provide analgesic effects without opioid-related side effects, providing specific insight into the cellular impact of opioid receptor-based activation as related to pain medications. These ligands could be used as a tool to negate drug tolerance and dependence as well as other adverse side effects.
Inventor(s): Thomas Prisinzano, Andrew Riley, Chad Groer

An Aryl Hydrocarbon (AHR) null rat model has been generated with the CRISPR/Cas9 editing system. The rat model may be used to study how exposure to environmental pollutants (especially dioxins), acting through AHR, shapes placental development.
Keyword(s): cancer
Inventor(s): Michael Soares, Khursheed Iqbal, Pramod Dhakal

Novel peptides designed for use as antibiotic potentiators to combat drug-resistant bacterial pathogens.
Inventor(s): Joanna Slusky

This is a novel seedless floating growth technique for synthesis of a variety of hybrid nanostructures on graphene, primarily for electronic and optoelectronic applications.
Inventor(s): Zhihong Wu, Jianwei Liu

This invention provides a composition and method for effectively and responsibly degrading polymers using an enzyme. It is most applicable in hydraulic fracturing (fracking) applications in the oil and gas industry. The system has the ability to break down a wide variety of fracking polymers without the use of toxic chemicals, and has the potential to degrade other organic molecules and pollutants associated with remediation processes.
Subcategory(s): oil-gas, petrochemicals, reagents
Keyword(s): crude, enzyme, petroleum
Inventor(s): Jenn-Tai Liang, Aaron Scurto, William Gilbert

This invention allows use of an efficient and stable oxygen evolution catalyst that facilitates water splitting without requiring noble metals or complicated synthesis methods.
Keyword(s): nano, solar
Inventor(s): Kevin Leonard, Joseph Barforoush, Tess Seuferling, Kelly Song

The invention consists of compounds for the treatment of parasitic diseases such as Trypanosomiasis and Leishmaniasis. Compounds are first-in-class, and selectively targeted towards pathogenic cells with nanomolar potency.
Category(s): therapeutics
Subcategory(s): small-molecules
Keyword(s): infectious-disease
Inventor(s): James Morris, Jeffrey Aube, Daniel Flaherty, Jennifer Golden, Elizabeth Sharlow

A new class of novel catalysts was prepared with high selectivity for the conversion ethane to ethylene. The invented catalyst could enable a new oxidative dehydrogenation process that would waste less carbon and require less energy than current methods of ethylene production.
Subcategory(s): oil-gas, petrochemicals
Keyword(s): nano, petroleum
Inventor(s): Feng Tao, Shiran Zhang, Juanjuan Liu

This invention utilizes a novel approach to achieve unprecedented accuracy for MEG/EEG medical imaging. Precisely isolating locations in the brain can play an important role in treatment procedures. Based on a variation of minimum mean-square error (MMSE) estimation, this approach is a solution to a previously unsolved problem in brain imaging. The approach has been applied to simulated brain MEG auditory response data and has enabled the capability of resolving, both temporally and spatially, the separate components of the primary and secondary auditory responses. This invention is able to precisely locate the primary and secondary responses. Further, this approach can be used in any application involving MEG/EEG imaging.
Subcategory(s): healthcare
Inventor(s): Tsz Ping Chan, Mihai Popescu, Shannon Blunt

The current invention is a novel composition of matter as well as a method for treating tumor metastasis, which utilizes the composition of matter to reduce the prevalence of the perinucleolar compartment (PNC) in cancer cells.
Subcategory(s): biologics, small-molecules
Keyword(s): cancer, regeneration, tissue
Inventor(s): Frank Schoenen, Kevin Frankowski