Novel ligands designed to activate mu opioid receptors and provide analgesic effects without opioid-related side effects, providing specific insight into the cellular impact of opioid receptor-based activation as related to pain medications. These ligands could be used as a tool to negate drug tolerance and dependence as well as other adverse side effects.
An Aryl Hydrocarbon (AHR) null rat model has been generated with the CRISPR/Cas9 editing system. The rat model may be used to study how exposure to environmental pollutants (especially dioxins), acting through AHR, shapes placental development.
This invention provides a composition and method for effectively and responsibly degrading polymers using an enzyme. It is most applicable in hydraulic fracturing (fracking) applications in the oil and gas industry. The system has the ability to break down a wide variety of fracking polymers without the use of toxic chemicals, and has the potential to degrade other organic molecules and pollutants associated with remediation processes.
The invention consists of compounds for the treatment of parasitic diseases such as Trypanosomiasis and Leishmaniasis. Compounds are first-in-class, and selectively targeted towards pathogenic cells with nanomolar potency.
A new class of novel catalysts was prepared with high selectivity for the conversion ethane to ethylene. The invented catalyst could enable a new oxidative dehydrogenation process that would waste less carbon and require less energy than current methods of ethylene production.
This invention utilizes a novel approach to achieve unprecedented accuracy for MEG/EEG medical imaging. Precisely isolating locations in the brain can play an important role in treatment procedures. Based on a variation of minimum mean-square error (MMSE) estimation, this approach is a solution to a previously unsolved problem in brain imaging. The approach has been applied to simulated brain MEG auditory response data and has enabled the capability of resolving, both temporally and spatially, the separate components of the primary and secondary auditory responses. This invention is able to precisely locate the primary and secondary responses. Further, this approach can be used in any application involving MEG/EEG imaging.
The current invention is a novel composition of matter as well as a method for treating tumor metastasis, which utilizes the composition of matter to reduce the prevalence of the perinucleolar compartment (PNC) in cancer cells.